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A new seismic-resilient structural system is being developed to protect buildings, their contents, and occupants during major earthquakes. This economical system is intended for essential facilities, such as hospitals, where damage to the buildings and contents and occupant injuries must be prevented and where continuity of operation is imperative. The primary components of the Frame-Spine-FLC System are: (1) steel base moment-resisting frames designed and detailed to behave in the inelastic range and dissipate energy, (2) stiff and strong elastic spines designed to remain essentially elastic to redistribute seismic demands more uniformly over the building height, and (3) force-limiting connections (FLC) that connect the frame to the spines to provide a yielding mechanism that limits acceleration demands. An international team, including three U.S. universities, two Japanese universities and two major experimental research labs, is collaborating on this project and recently conducted full-scale shake-table testing at the E-Defense facility in Miki, Japan. The test building represents a hospital facility and includes realistic nonstructural components and medical equipment. This paper provides an overview of the shake-table testing program and presents preliminary results that demonstrate the seismic stability response of the Frame-Spine-FLC System and the overall viability of the new concept.